The aim of the present study was to evaluate and compare the influence of accelerated-aging conditions on the drug content and in vitro dissolution stability of two different piroxicam non aqueous emulsions. Emulsions can be formulated without an aqueous phase to produce anhydrous, non-aqueous or oil-in-oil emulsions. Such systems, which can replace conventional emulsions where the presence of water is to be avoided, have been used for the preparation of nanoparticles or as templates in the formation of silicate microstructures. Dissolution efficiency (DE) was calculated from dissolution profiles that were performed according to the United State Pharmacopoeia monograph. This determination was performed at time zero, three and six months of storage; according to ICH accelerated-aging conditions (40°C/75% RH). Each formulation was compared with the reference at the specified times, using ANOVA in terms of DE and similarity factor f2. Furthermore, ANOVA for DE values was used to evaluate the effect of aging conditions on the dissolution stability within each formulation. Although the storage conditions examined in the study affected the dissolution behavior of all formulations, they did not have a significant effect on chemical stability, with the exception of one formulation that showed undesirable performance in both chemical and dissolution stability.
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